DRAGEN Array Applications
The following Types of Analysis are currently supported by DRAGEN Array:
DRAGEN Array – Genotyping
DRAGEN Array – PGx – CNV calling
DRAGEN Array – PGx – Star allele annotation
DRAGEN Array – Methylation QC
DRAGEN Array – CNV and LOH Calling
Product & Analysis Compatibility
These products/beadchips have been verified to be compatible with the following analyses and versions of DRAGEN Array:
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
UMD3
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh37, GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh37, GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – PGx – CNV calling
GRCh37, GRCh38
v1.0
v1.0
DRAGEN Array – PGx – Star allele annotate
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – PGx – CNV Calling
GRCh38
v1.1+
v1.1+
DRAGEN Array – PGx – Star allele annotate
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh37, GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – PGx – CNV Calling
GRCh38
v1.1+
v1.1+
DRAGEN Array – PGx – Star allele annotate
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – Genotyping
GRCh38
v1.0, v1.1
v1.0+
DRAGEN Array – PGx – CNV Calling
GRCh38
v1.1+
v1.1+
DRAGEN Array – PGx – Star allele annotate
GRCh38
v1.1+
v1.0+
DRAGEN Array – Genotyping
GRCh37
v1.0
N/A
DRAGEN Array – Methylation – QC
GRCh38
v1.0
N/A
DRAGEN Array – Methylation – QC
GRCh38
v1.0
N/A
DRAGEN Array – Methylation – QC
GRCh38
v1.2
v1.2
DRAGEN Array – CNV and LOH Calling – 1.2.0
GRCh37, GRCh38
v1.2
v1.2
DRAGEN Array – CNV and LOH Calling – 1.2.0
GRCh37, GRCh38
v1.2
v1.2
DRAGEN Array – CNV and LOH Calling – 1.2.0
GRCh37, GRCh38
DRAGEN Array – Genotyping
Summary
Provides genotyping results for any human Infinium genotyping array.
Variant types detected
SNV
Indel
Sample minimum
1 sample
Arrays supported
Related Local Commands
genotype call
genotype gtc-to-vcf
Related Cloud Specifics
Select Type of Analysis DRAGEN Array – Genotyping from the dropdown. Max 1152 samples are supported.
Inputs
Outputs
Per sample:
Per analysis batch:
Cost
DRAGEN Array – PGx – CNV calling
Summary
Provides CNV calling on 7 target PGx genes across 10 target regions, plus genotyping outputs.
Variant types detected
SNV
Indel
CNV
Sample minimum
Minimum of 24 samples with 22 passing QC defined as Log R Dev < 0.2. 96 samples are recommended for best results.
Arrays supported
Related Local Commands
genotype call
genotype gtc-to-vcf
[optional]
pgx copy-number call
Related Cloud Specifics
Select Type of Analysis DRAGEN Array – PGx – CNV calling from the dropdown. Max 384 samples are supported.
Inputs
Outputs
Per sample:
Per analysis batch:
Cost
DRAGEN Array – PGx – Star Allele Annotation
Summary
Provides PGx annotation on over 50 genes, plus PGx CNV and genotyping outputs
Variant types detected
SNV
Indel
CNV
Star allele diplotype
Sample minimum
Minimum of 24 samples with 22 passing QC defined as Log R Dev < 0.2. 96 samples are recommended for best results.
Arrays supported
Related Local Commands
genotype call
genotype gtc-to-vcf
pgx copy-number call
pgx star-allele call
pgx star-allele annotate
Related Cloud Specifics
Select Type of Analysis DRAGEN Array – PGx – Star Allele Annotation from the dropdown. Max 384 samples are supported.
Inputs
Outputs
Per sample:
Per analysis batch:
Cost
Local: Per sample analysis.
DRAGEN Array – Methylation QC
Summary
Provides methylation QC for Infinium methylation arrays.
Variant types detected
N/A
Sample minimum
1 sample
Arrays supported
Recommended thresholds and all built-in control probes are available for Methylation Screening Array (MSA) and MethylationEPIC (v1 & v2) originating from iScan. In non-human and custom arrays, availability of built-in QC probes may vary, and failure thresholds must be defined by the user.
Related Local Commands
Not available on DRAGEN Array Local.
Related Cloud Specifics
Inputs
Outputs
Cost
DRAGEN Array – CNV and LOH Calling
Summary
Provides cytogenetic genome-wide copy number and loss of heterozygosity calling
Variant types detected
CNV
LOH
Sample minimum
Minimum of 1 sample.
Arrays supported
Related Local Commands
genotype call
genotype gtc-to-vcf
[optional]
genotype gtc-to-bedgraph
cyto call
cyto annotate
Related Cloud Specifics
Select Type of Analysis DRAGEN Array – CNV and LOH Calling from the dropdown. Max 1152 samples are supported.
Inputs
Outputs
Per sample:
Per analysis batch:
Cost
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