DRAGEN Array Methylation QC Cloud v1.0.0 Release Notes

RELEASE DATE

May 2024

RELEASE HIGHLIGHTS

  • Adjustable thresholds to determine pass/fail status

  • Data summary plots for a quick visual check of each analysis batch

  • Determining detection p-value, beta-values, and m-values from each methylation sample

  • Deployment on BaseSpace™ Sequence Hub user interface for easy analysis kickoff

NEW FEATURES IN DETAIL

  • Adjustable thresholds for 21 built in controls, p-value detection, proportion probes passing, and offset correction within BaseSpace Sequence Hub to customize for user’s study needs

    • Thresholds are used to assign pass (1) or fail (0) status to each sample

      • Failed metrics can be highlighted for easy viewing

    • Pinpoint areas of failure including bisulfite conversion, staining, hybridization, etc. to identify assay steps in need of troubleshooting

    • Quantitative values for each control removing ambiguity with manual interpretation

  • Data summary plots with information on passing p-value detection and principal component analysis of beta values

  • Provides detection p-value, beta-values and m-values for each CG site per sample to use in downstream analysis

KNOWN ISSUES

KNOWN LIMITATIONS

  • Standard thresholds may not be applicable for all discontinued, semi-custom or custom BeadChips and IDATs originating from NextSeq550

  • Built-in controls may not be available on all discontinued, semi-custom or custom BeadChips

Last updated

For Research Use Only. Not for use in diagnostic procedures. © 2024 Illumina, Inc. All rights reserved.