DRAGEN Array Methylation QC Cloud v1.0.0 Release Notes

RELEASE DATE

May 2024

Adjustable thresholds to determine pass/fail status
Data summary plots for a quick visual check of each analysis batch
Determining detection p-value, beta-values, and m-values from each methylation sample
Deployment on BaseSpace™ Sequence Hub user interface for easy analysis kickoff

Adjustable thresholds for 21 built in controls, p-value detection, proportion probes passing, and offset correction within BaseSpace Sequence Hub to customize for user’s study needs
- Thresholds are used to assign pass (1) or fail (0) status to each sample
  - Failed metrics can be highlighted for easy viewing
- Pinpoint areas of failure including bisulfite conversion, staining, hybridization, etc. to identify assay steps in need of troubleshooting
- Quantitative values for each control removing ambiguity with manual interpretation
Data summary plots with information on passing p-value detection and principal component analysis of beta values
Provides detection p-value, beta-values and m-values for each CG site per sample to use in downstream analysis

Standard thresholds may not be applicable for all discontinued, semi-custom or custom BeadChips and IDATs originating from NextSeq550
Built-in controls may not be available on all discontinued, semi-custom or custom BeadChips

Last updated 2 months ago